H2020 EU New developments in Industrial Biocatalysis demonstration workshop

This workshop will explore the state of the art in industrial biocatalysis through the new technologies developed in the EU Horizon 2020 projects ROBOX and CARBAZYMES.

Preliminary programme:

10:00 Welcome and Introduction to the workshop

10:10 Introduction to ROBOX - Marco Fraaije project coordinator

10:20 Engineering oxidative enzymes

10:40 Producing oxidative enzymes

11:00 Industrial applications of P450 monooxygenases, Oxidases and

Baeyer-Villiger monooxygenases Martin Schürmann / Innosyn

11:40 Using oxidative enzymes for surface modifications Geert Deroover/ ChemStream

12:20 Lunch & Posters

14:20 Introduction to Carbazymes

Woody Fessner - project coordinator

14:30 Discovery & engineering of C-C bond forming enzymes

Woody Fessner / TU Darmstadt

15:00 Production of maximally diverse panels of novel enzymes

Simon Charnock / Prozomix

15:30 Insights into the application of C-C bond forming enzymes in an industrial environment

Rainer wardenga / Enzymicals

16:00 High substrate loadings & selectivity: Industrially-sound enzymatic C-C bond forming reactions

Pablo Domínguez / Sustainable Momentum

16:30 Close followed by, Networking Reception

ROBOX: Expanding the industrial use of Robust Oxidative Biocatalysts for the conversion and production of alcohols

Oxygen functionalities are key functional groups in many of today’s chemicals and materials. The efficient introductions of oxygen-functionalities into raw materials are key chemical transformations in bulk and fine chemicals. Innovative biocatalytic oxidation routes using molecular oxygen under benign and mild conditions can greatly improve the sustainability and economics of processes. Such processes have so far mainly been applied in the pharmaceuticals sector, where the enzyme-catalyzed step often represents the highest added value, and the high product price (> €1000/kg) justifies suboptimal enzyme production and limitations in catalytic efficiency. In order to achieve broader industrial application of enzymatic biooxidation processes in larger volume but lower price chemical markets, ROBOX has targeted demonstration of the techno-economic viability of biotransformations catalysed by four types of robust oxidative enzymes: P450 monooxygenases, Baeyer-Villiger MonoOxygenase, Alcohol Dehydrogenases and Alcohol Oxidases.

CARBAZYMES: Sustainable industrial processes based on a C-C bond-forming enzyme platform

C-C bond forming reactions are of central importance in industrial organic synthesis to create relevant new molecules from readily available material. However, the implementation of biocatalytic carboligation processes has remained a promising but largely unexplored potential due to a number of technical hurdles. CARBAZYMES has addressed such challenges through an interdisciplinary approach to achieve the biocatalytic synthesis of APIs and bulk chemicals corresponding to market needs. CARBAZYMES has targeted the biocatalytic synthesis of products identified by industrial partners in the consortium to meet market needs. The project targets syntheses at technical scale using a broad platform of 4 types of unique C-C bond-forming enzymes, as well as the capabilities to rapidly evolve those biocatalysts to operate under industrial process conditions.

Registration is free, including lunch and a networking reception. Please remember that non-attendance may still incur costs, so please notify the organiser as soon as possible if you are unable to attend for any reason.